|
KMID : 0617219960070010067
|
|
Duksung Bulletin Phamaceutical Sciences
1996 Volume.7 No. 1 p.67 ~ p.72
|
|
|
DETERMINATION OF WOUND HEALING EFFECT OF EPIDERMAL GROWTH FACTOR ON THE FIRST DEGREE BURN SKIN
|
|
Jung Kihwa
|
|
|
Abstract
|
|
|
|
To investigate the effect of EGF on the wound healing process of burn skin, histological study has been performed. Under strictly regulated experimental burn condition, the burn skin was prepared and the cytological observation was performed. Also micro auto-radiograph study of [2-^14C] thymidine uptake study has been conducted. EGF in 20 % gelatin gel film was applied on the burn skin area. At pre-determined post burn time, mice were sacrificied and the treated area was excised and processed for the cytological observation. The optimum burn condition (70℃, 10 sec burn) and the post-burn time (24hr) to observe the wound healing effect of EGF have been established. Labeling index of ^14C-thymidine incorporation into the nucleus of the cell can provide us the clear understanding of the wound healing effect of EGF.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|